Human Sera
Cayman Chemical IsoquercetIn 50mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical MethIdathIon 100mg
An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% at 3.5 mg/kg; selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival at 24 mg/kg; increases SCE and induces cell cycle arrest at the M1 phase in V79 cells at 40 μg/ml; increases liver enzyme activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs from 1.4-4.7 mg/kg; induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats 5 mg/kg
Cayman Chemical ScutelarIn 100mg
A flavone with diverse biological activities; inhibits proliferation of PC-9 and H1975 NSCLC cells and induces apoptosis and autophagy at 160 µM; reduces tumor growth in an H1975 mouse xenograft model at 30 and 60 mg/kg per day; decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of NAFLD at 25 and 50 mg/kg; decreases hepatic MDA, GOT, GPT activity, increases CAT and T-AOC activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in a mouse model of NAFLD; prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively at 5, 25, and 50 mg/kg per day
Cayman Chemical PomalIdomID 4alkylC6amIn 100mg
A PROTAC building block; has been used in the synthesis of PROTACs that drive HDAC8 degradation
Cayman Chemical 2Fluoro2deoxyarabInoCy 50mg
A fluorinated derivative of 2'-deoxycytidine; cytotoxic to CCRF-HSB-2, COLO 320DM, and MKN28 cancer cells (IC50s = 0.15, 0.19, and 29 UG/ml, respectively); inhibits HIV-1 replication in HIV-1-infected C8166 cells (IC50 = 0.7 µM); inhibits HSV-1 and HSV-2 replication in HSV-1- or HSV-2-infected Vero cells (IC50s = 0.12 and 0.3 µM, respectively)
Cayman Chemical AcoramIdIshydrochlorIde 50mg
A TTR kinetic stabilizer; selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively; Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all); inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I, indicating tetramer stabilization; stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy at 10 µM
Cayman Chemical EntecavIrhydrate 100mg
An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg
Cayman Chemical TopIroxostat 50mg
An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); inhibits ABCG2 in isolated human plasma (IC50 = 0.18 µM); increases LPS-induced decreases in Bcl-2 levels and decreases LPS-induced increases of Bax and cleaved caspase-3 levels in H9c2 rat cardiomyocytes at 5 µM; chronic administration results in the presence of urinary xanthine crystals and induces nephropathy in rats at 0.2 and 1 mg/kg, respectively
Cayman Chemical LasofoxIfentartrate 50mg
A third-generation SERM that selectively binds to human ERα (IC50 = 1.5 nM) and inhibits bone loss in ovariectomized rats; used in the treatment of postmenopausal osteoporosis and ER-positive breast cancer; also acts as an inverse agonist at the CB2 cannabinoid receptor
Cayman Chemical NaloxonhydrochlorIde 100mg
An analytical reference standard categorized as an opioid antagonist; formulations containing it have been used as antidotes for opioid overdose and the prevention of overdose; formulations containing it have also been used in the treatment of opiate addiction and in pain management; intended for research and forensic applications
Cayman Chemical VulpInIc AcId 100mg
A lichen metabolite with diverse biological activities; active against various bacteria (MICs = 4-16 μg/ml); prevents UVB-induced apoptosis, cytotoxicity, and cytoskeletal modifications in HaCaT human keratinocytes from 25-800 μM; increases scratch wound healing of HaCaT cells; reduces hydrogen peroxide-induced production of ROS and cytotoxicity in HUVECs at 15 μM
Cayman Chemical ElvItegravIr 100mg
A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)
Cayman Chemical 5a-ndrost-16-en-3a-ol 100mg
A pheromone with diverse biological activities; enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM); increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors from 0.1-1 µM; has antidepressant-like effects in mice from 5-10 mg/kg; has anxiolytic-like effects in mice from 30-50 mg/kg; protects against PTZ- or electroshock-induced seizures in mice (ED50s = 48.9 and 21.9 mg/kg, respectively)
Cayman Chemical 7Methoxy4 trIfluoromethyl 50mg
A fluorogenic substrate for CYPs; HFC is released upon enzymatic cleavage by CYPs and its fluorescence can be used to quantify CYP activity; ex/em = 410/510 nm, respectively
Cayman Chemical VIlazodonhydrochlorIde 50mg
An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg